Imaging features of toxicities associated with immune checkpoint inhibitors. (2022)

• Record Type: Journal Article
• Authors: Gosangi, Babina; McIntosh, Lacey; Keraliya, Abhishek; Irugu, David Victor Kumar; Baheti, Akshay; Khandelwal, Ashish; Thomas, Richard; Braschi-Amirfarzan, Marta
• Is Part Of: European journal of radiology open. Volume 9(2022)
• Publication Date: 2022
• Subjects: Immune check point inhibitors toxicity -- Pneumonitis -- Colitis -- Pancreatitis -- Hepatitis; ICI Immune check point inhibitor -- CTLA-4 inhibitor Cytotoxic T-lymphocyte antigen- 4 inhibitor -- PD-L1 inhibitor programmed cell death ligand-1 inhibitor -- PD-1 inhibitor programmed cell death-1 inhibitor -- irAE immune-related adverse event -- CTCAE Common Terminology Criteria for Adverse Events -- PFS progression free survival -- RRP radiation recall pneumonitis -- FDA Food and Drug Administration -- NSCLC non-small cell lung cancer -- OP organizing pneumonia -- NSIP non-specific interstitial pneumonia -- AIP acute interstitial pneumonitis -- ARDS acute respiratory distress syndrome -- LGE late Gadolinium enhancement; Medical radiology -- Periodicals; 616.075705
• DOI: 10.1016/j.ejro.2022.100434
• Languages: English
• ISSNs: 2352-0477

Abstract

Abstract: The past decade has witnessed a change in landscape of cancer management with the advent of precision oncology. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment and have played an important role in improving patient survival. While the patients are living longer, treatment with ICIs are sometimes associated with adverse effects, some of which could be fatal. Radiologists can play a crucial role by early identification of some of these adverse effects during restaging scans. Our paper focuses on the imaging features of commonly occurring ICI toxicities based on organ system.