Resolvins Lipid Mediators: Potential Therapeutic Targets in Alzheimer and Parkinson Disease. (15th December 2022)

• Record Type: Journal Article
• Authors: Anand, Santosh; Azam Ansari, Mohammad; Kumaraswamy Sukrutha, Sambamurthy; Alomary, Mohammad N.; Anwar Khan, Anmar; Elderdery, Abozer Y.
• Is Part Of: Neuroscience. Volume 507(2022)
• Page Start: 139
• Page End: 148
• Publication Date: 2022-12-15
• Subjects: resolvins -- lipid mediators -- arachidonic acid -- Alzheimer's disease -- Parkinson's disease; AA Arachidonic acid -- COX Cyclooxygenase -- PMNs Polymorphonuclear cells -- SPM Specialized pro-resolving mediators -- EPA Eicosapentaenoic acid -- DHA Docosahexaenoic acid -- TXA2 Thromboxane A2 -- GPCR G protein-coupled receptors -- CRTH Chemoattractant receptor-homologous -- HPETEs Hydroperoxyeicosatetraenoic acids -- LXs Lipoxins -- EETs Epoxyeicosatrienoic acids -- LOX Lipooxygenase -- RvEs Resolvin E series -- RvDs Resolvin D series -- AD Alzheimer's disease -- ChemR23 Chemerin receptor 23 -- BLT1 Leukotriene B4 receptor -- PD Parkinson's disease; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2022.11.001
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Highlights: Resolvins play a vital role in the resolution of inflammation. Resolvins mediate the production of anti-inflammatory mediators and suppresses proinflammatory mediators. D-series resolvins supports Aβ phagocytosis by modulating PI3K/Akt/mTOR, MEK1/2, and PKA cascades. Resolvins orchestrates the resolution of inflammation in in vitro and in vivo PD models. Abstract: Inflammation and resolution are highly programmed processes involving a plethora of immune cells. Lipid mediators synthesized from arachidonic acid metabolism play a pivotal role in orchestrating the signaling cascades in the game of inflammation. The majority of the studies carried out so far on inflammation were aimed at inhibiting the generation of inflammatory molecules, whereas recent research has shifted more towards understanding the resolution of inflammation. Owing to chronic inflammation as evident in neuropathophysiology, the resolution of inflammation together with the class of lipid mediators actively involved in its regulation has attracted the attention of the scientific community as therapeutic targets. Both omega-three polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, orchestrate a vital regulatory role in inflammation development. Resolvins derived from these fatty acids comprise the D-and E-series resolvins. A growing body of evidence using in vitro and in vivo models has revealed the pro-resolving and anti-inflammatory potential of resolvins. This systematic review sheds light on the synthesis, specialized receptors, and resolution of inflammation mediated by resolvins in Alzheimer's and Parkinson's disease.