Inflammatory cytokines and their correlations with different left ventricular geometries and functions in PHT patients. Issue 12 (14th November 2022)

• Record Type: Journal Article
• Authors: Zan, Yu; Wang, Jian; Wang, Wenjuan; Cui, Tong; Xu, Kun; Li, Yiying; Huang, Xiaochun; Zhang, Yanjing; Wei, Na; Xing, Xueqing
• Is Part Of: Echocardiography. Volume 39:Issue 12(2022)
• Page Start: 1589
• Page End: 1600
• Publication Date: 2022-11-14
• Subjects: automatic two‐dimensional speckle‐tracking study -- echocardiography -- essential hypertension -- inflammatory cytokines -- left ventricular geometry; Echocardiography -- Periodicals; Echocardiography -- Periodicals; 616.1207543
• DOI: 10.1111/echo.15495
• Languages: English
• ISSNs: 0742-2822

Abstract

Abstract: Objectives: To investigate relationships between hypersensitive C‐reactive protein (hs‐CRP), tumor necrosis factor ‐α (TNF‐α), interleukin‐17A (IL‐17A), and interferon ‐γ (IFN‐γ), with left ventricular geometry (LVG) and function in patients with primary hypertension (PHT). Methods: A total of 396 PHT patients were assigned into four groups: Normal Geometry (NG), Concentric Remodeling (CR), Eccentric Hypertrophy (EH), and Concentric Hypertrophy (CH). The correlation between hs‐CRP, TNF‐α, IL‐17A, IFN‐γ, and clinical, biochemical parameters were analyzed by Pearson correlation analysis and Logistic regression. Receiver Operating Characteristic (ROC) curve was used to analyze the clinical values of hs‐CRP, TNF‐α, IL‐17A, and IFN‐γ for abnormal LVG prediction. Results: NG, CR, EH, and CH group all presented increasingly higher levels of Hs‐CRP, TNF‐α, IL‐17A, and IFN‐γ, and the increase was the most prominent in the CH group. Pearson correlation analysis showed that hs‐CRP, IL‐17A, and IFN‐γ were all positively correlated with LASct. Hs‐CRP, TNF‐α, and IL‐17A were all negatively correlated with GLS, LASr, and LAScd. However, IFN‐γ was only negatively correlated with GLS and LAScd. Logistic regression analysis showed that hs‐CRP and IL‐17A were independently correlated with CR; hs‐CRP, TNF‐α, IFN‐γ, and IL‐17A were independently correlated with EH and CH. ROC curve analysis showed that the area under the curve (AUC) of hs‐CRP was 0.816. When the optimal diagnostic threshold of hs‐CRP was 3.04 mg/L, the sensitivity and specificity of the abnormal LVG were 72.1% and 81.5%, respectively. Conclusion: In PHT patients, hs‐CRP, TNF‐α, IL‐17A, and IFN‐γ were correlated with abnormal LVG and left ventricular function, suggesting that inflammatory cytokines may be involved in the process of PHT‐induced abnormal left ventricular structure and function. In addition, hs‐CRP can be used as a health screening index for patients at high risk of abnormal LVG.