A Convenient Synthesis of 5-substituted 2-amino-1, 3, 4-oxadiazoles from Corresponding Acylthiosemicarbazides Using iodine and Oxone®. (January 2013)

• Record Type: Journal Article
• Authors: Shinde, Vikas N.; Ugarkar, Bheemarao G.; Ghorpade, Sandeep R.
• Is Part Of: Journal of chemical research. Volume 37:Number 1(2013)
• Page Start: 53
• Page End: 54
• Publication Date: 2013-01
• Subjects: oxone -- oxadiazole -- acylthiosemicarbazides; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751912X13551638283701
• Languages: English
• ISSNs: 1747-5198

Abstract

A convenient methodology has been developed for the synthesis of substituted 2-amino-1, 3, 4-oxadiazoles from corresponding acylthiosemicarbazides using catalytic amount of iodine/KI in the presence of Oxone® as a bulk oxidant. This offers the advantage of short reaction times and substrate variability which is suitable for the rapid production of analogues required for lead optimisation programmes. The method could also be useful for large-scale synthesis because of the mild reaction conditions and the use commercially inexpensive and safe reagents.