Three Novel Friedelane Triterpenes with Antimicrobial Activity from the Stems of Celastrus Monospermus. (January 2013)

• Record Type: Journal Article
• Authors: Xie, Haiping; Chen, Mingxiang; Wang, Dingyong; Xu, Runlin
• Is Part Of: Journal of chemical research. Volume 37:Number 1(2013)
• Page Start: 14
• Page End: 18
• Publication Date: 2013-01
• Subjects: Celastrus monospermus -- friedelane triterpene -- monospermonal -- antimicrobial activity; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751912X13543807337784
• Languages: English
• ISSNs: 1747-5198

Abstract

Three novel friedelane triterpenes, monospermonal, monospermonol and monospermondiol, along with six known friedelanes, 3-oxofriedelane, 3-oxofriedelan-28-al, 3, 12-dioxofriedelane, 3-oxo-28-hydroxyfriedelane, 3-oxo-11 β -hydroxyfriedelane, 3-oxo-12 α -hydroxyfriedelane and an oleanane triterpenoid, 3 β -hydroxyolean-12-ene, were isolated from the stems of Celastrus monospermus Roxb. The structures of novel compounds, monospermonal, monospermonol and monospermondiol, were identified as 3, 12-dioxofriedelan-28-al, 3, 12-dioxo-28-hydroxyfriedelane and 3-oxo-12 α, 28-dihydroxyfriedelane, respectively by spectroscopies including 2D NMR methods. These nine friedelane-type triterpenes were tested for antimicrobial activity against luminescent bacterium Photobacterium leiognathi N1 that had been isolated from "glowing" fish meat. Monospermonal and monospermonol showed moderate activity.