Diagnostic value of ophthalmic artery Doppler indices for prediction of preeclampsia at 28–32 weeks of gestation. Issue 1 (6th July 2022)

• Record Type: Journal Article
• Authors: Saleh, Maasoumeh; Naemi, Mahsa; Aghajanian, Sepehr; Saleh, Mahboubeh; Hessami, Kamran; Bakhtiyari, Mahmood
• Is Part Of: International journal of gynaecology and obstetrics. Volume 160:Issue 1(2023)
• Page Start: 120
• Page End: 130
• Publication Date: 2022-07-06
• Subjects: doppler ultrasonography -- ophthalmic artery -- preeclampsia -- pregnancy‐associated plasma protein‐A -- uterine artery; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.14305
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: The aim of this study was to examine the diagnostic value of ophthalmic artery Doppler indices in predicting preeclampsia along with other markers in the third trimester of pregnancy. Methods: Normotensive pregnancies were included during 28–32 weeks of gestation to undergo uterine and ophthalmic artery Doppler ultrasound. Maternal and fetal characteristics were documented at the visit between the 28 and 32 weeks of gestation, and pregnancy‐associated plasma protein A (PAPP‐A) values in the first trimester were collected to be integrated into a multiparametric prediction model. Results: Of 795 included participants, 48 cases progressed to preeclampsia. All assessed ophthalmic Doppler parameters including first and second peak systolic velocities (PSVs), second to first peak ratio (PR), and pulsatility index (PI), were statistically different in patients who developed preeclampsia later on. The average PR (sensitivity: 100% [95% CI, 0.81–1.00]; specificity: 90% [95% CI, 0.86–0.93]) and PI between the eyes, PAPP‐A multiple of median and uterine artery PI were determined to be the most important predictors of PE, which were subsequently integrated into a multiple regression model (sensitivity: 94% [95% CI, 0.70–1.00]; specificity: 93% [95% CI, 0.89–0.96]). Conclusion: This study provided a screening method for individuals at higher risk of progressing to preeclampsia in the third trimester of pregnancy. Synopsis: This study proposes a multiparametric model for predicting preeclampsia using ophthalmic artery Doppler indices, thereby screening individuals with higher risk of developing preeclampsia.