Photoswitchable Microgels for Dynamic Macrophage Modulation. Issue 49 (2nd November 2022)
- Record Type:
- Journal Article
- Title:
- Photoswitchable Microgels for Dynamic Macrophage Modulation. Issue 49 (2nd November 2022)
- Main Title:
- Photoswitchable Microgels for Dynamic Macrophage Modulation
- Authors:
- Kim, Yuri
Thangam, Ramar
Yoo, Jounghyun
Heo, Jeongyun
Park, Jung Yeon
Kang, Nayeon
Lee, Sungkyu
Yoon, Jiwon
Mun, Kwang Rok
Kang, Misun
Min, Sunhong
Kim, Seong Yeol
Son, Subin
Kim, Jihwan
Hong, Hyunsik
Bae, Gunhyu
Kim, Kanghyeon
Lee, Sanghyeok
Yang, Letao
Lee, Ja Yeon
Kim, Jinjoo
Park, Steve
Kim, Dong‐Hyun
Lee, Ki‐Bum
Jang, Woo Young
Kim, Bong Hoon
Paulmurugan, Ramasamy
Cho, Seung‐Woo
Song, Hyun‐Cheol
Kang, Seok Ju
Sun, Wujin
Zhu, Yangzhi
Lee, Junmin
Kim, Han‐Jun
Jang, Ho Seong
Kim, Jong Seung
Khademhosseini, Ali
Kim, Yongju
Kim, Sehoon
Kang, Heemin
… (more) - Abstract:
- Abstract: Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly or under non‐physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via π–cation and π–π interactions are developed that are electrostatically stabilized with Arg–Gly–Asp (RGD)‐bearing anionic polymers. Lateral swelling of RGD‐bearing microgels occurs via cis ‐azobenzene formation mediated by near‐infrared‐light‐upconverted ultraviolet light, which disrupts intermolecular interactions on the visible‐light‐absorbing upconversion‐nanoparticle‐coated materials. Real‐time imaging and molecular dynamics simulations demonstrate the deswelling of RGD‐bearing microgels via visible‐light‐mediated trans ‐azobenzene formation. Near‐infrared light can induce in situ swelling of RGD‐bearing microgels to increase RGD availability and trigger release of loaded interleukin‐4, which facilitates the adhesion structure assembly linked with pro‐regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD‐bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro‐inflammatory polarization. These microgels exhibit high stability and non‐toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells. Abstract : Remote control ofAbstract: Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly or under non‐physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via π–cation and π–π interactions are developed that are electrostatically stabilized with Arg–Gly–Asp (RGD)‐bearing anionic polymers. Lateral swelling of RGD‐bearing microgels occurs via cis ‐azobenzene formation mediated by near‐infrared‐light‐upconverted ultraviolet light, which disrupts intermolecular interactions on the visible‐light‐absorbing upconversion‐nanoparticle‐coated materials. Real‐time imaging and molecular dynamics simulations demonstrate the deswelling of RGD‐bearing microgels via visible‐light‐mediated trans ‐azobenzene formation. Near‐infrared light can induce in situ swelling of RGD‐bearing microgels to increase RGD availability and trigger release of loaded interleukin‐4, which facilitates the adhesion structure assembly linked with pro‐regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD‐bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro‐inflammatory polarization. These microgels exhibit high stability and non‐toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells. Abstract : Remote control of microgels via tissue‐penetrative light is demonstrated. Near‐infrared‐light‐upconverted ultraviolet light stimulates in situ swelling of RGD‐bearing microgels that increases RGD availability, thereby facilitating macrophage adhesion linked with pro‐regenerative polarization. Visible light induces the deswelling of RGD‐bearing microgels that decreases RGD availability that suppresses macrophage adhesion that yields pro‐inflammatory polarization. … (more)
- Is Part Of:
- Advanced materials. Volume 34:Issue 49(2022)
- Journal:
- Advanced materials
- Issue:
- Volume 34:Issue 49(2022)
- Issue Display:
- Volume 34, Issue 49 (2022)
- Year:
- 2022
- Volume:
- 34
- Issue:
- 49
- Issue Sort Value:
- 2022-0034-0049-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2022-11-02
- Subjects:
- dynamic hydrogels -- macrophage adhesion -- macrophage polarization -- microgel swelling -- photoswitchable microgels
Materials -- Periodicals
Chemical vapor deposition -- Periodicals
620.11 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4095 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/adma.202205498 ↗
- Languages:
- English
- ISSNs:
- 0935-9648
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0696.897800
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 24676.xml