Magnetic Nanodroplets for Enhanced Deep Penetration of Solid Tumors and Simultaneous Magnetothermal‐Sensitized Immunotherapy against Tumor Proliferation and Metastasis. Issue 23 (3rd October 2022)

• Record Type: Journal Article
• Authors: Wang, Junrui; Zhang, Wenli; Xie, Zhuoyan; Wang, Xingyue; Luo, Ying; Jiang, Weixi; Liu, Yun; Wang, Zhigang; Ran, Haitao; Song, Weixiang; Guo, Dajing
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 23(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-03
• Subjects: immunotherapy -- magnetic droplet vaporization -- magnetic fluid hyperthermia -- nanoultrasonic biomedicines -- solid tumors; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202201399
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The central cells of solid tumors are more proliferative and metastatic than the marginal cells. Therefore, more intelligent strategies for targeting cells with deep spatial distributions in solid tumors remain to be explored. In this work, a biocompatible nanotheranostic agent with a lipid membrane‐coated, Fe3 O4 and perfluoropentane (PFP)‐loaded, cRGD peptide (specifically targeting the integrin α v β 3 receptor)‐grafted, magnetic nanodroplets (MNDs) is developed. The MNDs exhibit excellent magnetothermal conversion and controllable magnetic hyperthermia (MHT) through alternating magnetic field regulation. Furthermore, MHT‐mediated magnetic droplet vaporization (MDV) induces the expansion of the MNDs to transform them into ultrasonic microbubbles, increasing the permeability of tissue and the cell membrane via the ultrasound‐targeted microbubble destruction (UTMD) technique and thereby promoting the deep penetration of MNDs in solid tumors. More importantly, MHT not only causes apoptotic damage by downregulating the expression of the HSP70, cyclin D1, and Bcl‐2 proteins in tumor cells but also improves the response rate to T‐cell‐related immunotherapy by upregulating PD‐L1 expression in tumor cells, thus inhibiting the growth of both primary and metastatic tumors. Overall, this work introduces a distinct application of nanoultrasonic biomedicine in cancer therapy and provides an attractive immunotherapy strategy for preventing the proliferation and metastasis of deeply distributed cells in solid tumors. Abstract : In this manuscript, magnetic nanolipid droplets (MNDs) for treating the cells in deep regions of solid tumors are reported. This work introduces a distinct application of nanoultrasonic biomedicine in cancer therapy and provides an attractive immunotherapy strategy (SMSI) for preventing the proliferation and metastasis of deeply distributed cells in solid tumors.