Caesium Iodide as an Efficient Catalyst for Synthesis of N-Substituted Azepines via Tandem Michael Addition and Cyclisation under Aqueous Conditions. (December 2013)

• Record Type: Journal Article
• Authors: Eshghi, Hossein; Momen, Sara; Gholizadeh, Mostafa; Vakili, Mohammad
• Is Part Of: Journal of chemical research. Volume 37:Number 12(2013)
• Page Start: 724
• Page End: 726
• Publication Date: 2013-12
• Subjects: N-substituted azepines -- aqueous conditions -- 2, 5-dimethoxytetrahydrofuran -- aromatic amines -- acetylene dicarboxylate -- CsI; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751913X13824449342828
• Languages: English
• ISSNs: 1747-5198

Abstract

A one-pot synthesis of N-substituted azepines under aqueous conditions is described. The synthesis of several azepines derivatives was carried out by reaction of 2, 5-dimethoxytetrahydrofuran, aromatic amines and dimethyl/diethyl acetylene dicarboxylate in the presence of CsI in water at ambient temperature. Products were obtained in high yields and catalyst was recovered and reused without a significant decrease in catalytic activity.