Synthesis, Antimalarial and Antileishmanial Activity of Novel 13-Benzyl-15, 16-Bisnorlabdane Derivatives. (November 2013)

• Record Type: Journal Article
• Authors: Salazar, Franklin J.; Quintero, Alberto; de Domínguez, Neira Gamboa; Concepción, Juan L.; Acosta, María E.; Tropper, Eleonora; Villamizar, José E.
• Is Part Of: Journal of chemical research. Volume 37:Number 11(2013)
• Page Start: 657
• Page End: 661
• Publication Date: 2013-11
• Subjects: bisnorlabdanes -- hemozoin formation inhibitors -- antimalarial -- antileishmanial; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751913X13794472538261
• Languages: English
• ISSNs: 1747-5198

Abstract

Twelve 13-benzyl-15, 16-bisnorlabdanes in which the C-13 and C-14 substituents are varied have been prepared from the naturally occurring labdane diterpene (+)-manool. These synthesised compounds were evaluated for antimalarial activity, in vitro as hemozoin formation inhibitors and in vivo against Plasmodium berghei . These derivatives were also assayed for antileishmanial activity against Leishmania mexicana .