A Convenient Synthesis of 4-amino-2-fluoro-N-methyl-benzamide. (October 2013)

• Record Type: Journal Article
• Authors: Xu, Defeng; Xu, Xing; Zhu, Zhiling
• Is Part Of: Journal of chemical research. Volume 37:Number 10(2013)
• Page Start: 615
• Page End: 616
• Publication Date: 2013-10
• Subjects: oxidation -- amination -- hydrogenation -- phase transfer catalyst; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751913X13787959772340
• Languages: English
• ISSNs: 1747-5198

Abstract

A convenient and concise synthesis of 2-Fluoro-4-nitrobenzoic acid was obtained by oxidation of 2-fluoro-4-nitrotoluene with potassium permanganate in the presence of a phase transfer catalyst in 74% yield. N-methyl-2-fluoro-4-nitrobenzamide was then produced via chlorination and amination in 95% yield. Hydrogenation in the presence of Pd/C can afforded 4-amino-2-fluoro-N-methyl-benzamide in 98% yield