Palladium-catalyzed interannular C–H amination of biaryl amines. Issue 98 (21st November 2022)

• Record Type: Journal Article
• Authors: Wu, Jiaping; Sun, Pengpeng; Hong, Yuwen; Yang, Haitao; Xie, Meihua; Zhang, Jitan
• Is Part Of: Chemical communications. Volume 58:Issue 98(2022)
• Page Start: 13620
• Page End: 13623
• Publication Date: 2022-11-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc05129j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A palladium-catalyzed interannular C–H amination of biaryl amines with O -benzoylhydroxylamines is reported, thus affording structurally diverse 2, 2′-diaminobiaryls. Abstract : A palladium-catalyzed interannular C–H amination of biaryl amines with O -benzoylhydroxylamines is reported. This reaction undergoes smoothly with operational practicality and good tolerance of functional groups, thereby providing a concise synthesis of 2, 2′-diaminobiaryls. Moreover, the readily accessible scale-up synthesis and the ability to transform the products into structurally diverse N-containing heterocycles demonstrate the synthetic potential of this catalytic protocol.