A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells. Issue 99 (29th November 2022)

• Record Type: Journal Article
• Authors: Song, Quanquan; Li, Qian; Chao, Shuang; Chen, Xian; Li, Ronghui; Lu, Yuchao; Aastrup, Teodor; Pei, Zhichao
• Is Part Of: Chemical communications. Volume 58:Issue 99(2022)
• Page Start: 13731
• Page End: 13734
• Publication Date: 2022-11-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc05788c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A dynamic reversible phenylboronic acid sensor for real-time determination of protein–carbohydrate interactions on living cancer cells. Abstract : Real-time detection of glycosylation on label-free cancer cell surfaces is of significance for the diagnosis and treatment of cancer. In this work, we have successfully developed a novel dynamic reversible sensor based on pH-sensitive phenylboronic esters to determine in real-time the binding kinetics of protein–carbohydrate interactions on suspension cancer cell surfaces using a quartz crystal microbalance (QCM) technique.