A major outbreak of the COVID-19 on the Diamond Princess cruise ship: Estimation of the basic reproduction number. Issue 12 (4th October 2022)

• Record Type: Journal Article
• Authors: Chou, Yu-Ching; Lin, Yu-Ju; Shie, Shian-Sen; Tsai, Hung-Bin; Sheng, Wang-Huei
• Is Part Of: Journal of the Chinese Medical Association. Volume 85:Issue 12(2022)
• Page Start: 1145
• Page End: 1153
• Publication Date: 2022-10-04
• Subjects: Basic reproduction number -- Cluster infection -- COVID-19 -- Diamond Princess cruise ship -- Nonlinear least-square curve fitting; Medicine -- Periodicals; 610.5
• DOI: 10.1097/JCMA.0000000000000820
• Languages: English
• ISSNs: 1726-4901

Abstract

Abstract : Background: The COVID-19 pandemic, which broke out in Wuhan, China, in 2019, was declared an international public health emergency by the World Health Organization on January 31, 2020. The outbreak on the Diamond Princess cruise ship had appeared first as a cluster infection outside China during the early pandemic. The incident occurred on February 1, 2020, involved an 80-year-old Hong Kong man who was diagnosed with COVID-19. The cruise ship docked in Yokohama, Japan, for 14 days of onboard quarantine; however, cluster infection outbroke rapidly. Methods: We constructed a SIR mathematical model and conducted an epidemiological study of the COVID-19 outbreak on the Diamond Princess cruise ship, covering the period from February 5 (start of quarantine) to February 20 (completion of 14-day quarantine). We estimated the basic reproduction number (R0 ) using a novel method of nonlinear least-squares curve fitting under Microsoft Excel Solver. The 95% confidence interval (CI) values were estimated by the jackknife procedures. Results: Six hundred thirty-four (17.1%) cases were diagnosed in a total population of 3711 cruise passengers, and 328 (51.7%) cases were asymptomatic. As of April 24, 2020, 712 cases had been diagnosed and 14 (1.96%) deaths had occurred. The R0 with 95% CI of the COVID-19 outbreak was 3.04 (2.72–3.36). Without an evacuation plan for passengers and crew, we estimated the total number of cumulative cases would reach 3498 (CI, 3464–3541). If the R0 value was reduced by 25% and 50%, the cumulative cases would be reduced to 3161 (CI, 3087-3254) and 967 (CI, 729-1379), respectively. The abovementioned R0 value was estimated from the original Wuhan strain. Conclusion: Cruise conditions would accelerate the spread of infectious diseases and were not suitable for onboard quarantine. Early evacuation and isolation of all passengers and crew members would reduce the R0 value and avoid further infections.