Vasorelaxant and Antihypertensive Effects of Bergenin on Isolated Rat Aorta and High Salt-Induced Hypertensive Rats. (22nd November 2022)

• Record Type: Journal Article
• Authors: Ahmad, Taseer; Qayyum, Rahila; Khan, Taous; Mahnashi, Mater H.; Jalal, Mohammed M.; Altayar, Malik A.; Alshehri, Osama M.; Shah, Abdul Jabbar
• Other Names: Riaz Muhammad Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2022(2022)
• Publication Date: 2022-11-22
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2022/4886193
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Bergenin is a phenolic glycoside that has been reported to be present in some medicinal plants which are traditionally used for their antihypertensive actions. So, bergenin was investigated for antihypertensive and vasorelaxant experiments in a rat model. Bergenin produced a significant fall in the mean arterial pressure (MAP) of rats. To explore the involvement of NO and muscarinic receptors, rats were pretreated with L-NAME and atropine in-vivo . The L-NAME did not change significantly the effect of bergenin on MAP excluding the involvement of NO. Unlike the L-NAME, atropine pretreatment reduced the effect of bergenin on MAP, indicating the role of muscarinic receptors. In in-vitro study, the bergenin produced endothelium-dependent (at lower concentrations) and independent (at higher concentrations) vasorelaxation, which was attenuated significantly in the presence of atropine and indomethacin but not with L-NAME. While a partial response was observed against K + -induced contractions. This was further confirmed when bergenin partly shifted the CaCl2 -CRCs toward right. Bergenin also suppressed the PE peak formation, indicating the antagonist effect against the release of Ca 2+ . Moreover, the bergenin-induced vasorelaxant response was not markedly attenuated with TEA, while significantly ablated with 4-AP and BaCl2 . In conclusion, the antihypertensive effects of bergenin are due to Ca 2+ channel blockade, K + channels activation, and muscarinic receptor-linked vasodilation.