Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach. (16th November 2022)

• Record Type: Journal Article
• Authors: Ma, Yuanyuan; Ma, Ruiting; ZhiGui, ; Sa, QiLa; Zhao, Na; Wurigumala, ; Burentegusi, ; Guo, Zhigang; Tumenwuliji,
• Other Names: Youssef Fadia S. Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2022(2022)
• Publication Date: 2022-11-16
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2022/8197364
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Background . Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. Purpose . This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. Methods . An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome and metabolome of XRG-4. Result . A total of 106 constituents were identified in XRG-4. Eighty-nine components were identified in biological samples, including 78 in urine (24 prototypes and 54 metabolites), 26 in feces (19 prototypes and 7 metabolites), and 9 in plasma (5 prototypes and 4 metabolites). In other tissues, only a few compounds, including alkaloids and iridoids, were detected. Conclusion . This comprehensive investigation of the chemical and metabolic profiles of XRG-4 provides a scientific foundation for its quality control and administration of clinically-safe medication.