External validation of the ACUTE HF score for risk stratification in acute heart failure. (1st January 2023)

• Record Type: Journal Article
• Authors: Kaneko, Tomohiro; Kagiyama, Nobuyuki; Nakamura, Yutaka; Dotare, Taishi; Sunayama, Tsutomu; Ishiwata, Sayaki; Maeda, Daichi; Iso, Takashi; Kato, Takao; Suda, Shoko; Hiki, Masaru; Matsue, Yuya; Kasai, Takatoshi; Minamino, Tohru
• Is Part Of: International journal of cardiology. Volume 370(2023)
• Page Start: 396
• Page End: 401
• Publication Date: 2023-01-01
• Subjects: Acute heart failure -- Risk score -- Echocardiography; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2022.10.130
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: The ACUTE HF score is a simple risk score that predicts the prognosis of patients with acute heart failure (HF) using clinical and echocardiographic parameters. As this score was developed for a small European population, we aimed to validate this score in an external population. Methods and results: This retrospective observational cohort analysis included patients hospitalized with acute HF during 2015–2019. Of 744 patients, 703 patients with available ACUTE HF scores were analyzed (75 ± 13 years; 61% male; left ventricular ejection fraction [LVEF] 49 ± 17%). Approximately one-third (34.4%) of the patients had reduced LVEF (<40%), and 51.4% exhibited preserved LVEF (≥50%). During a median follow-up of 452 days, primary and secondary outcomes were observed in 110 and 204 patients, respectively. The ACUTE HF score successfully stratified patients for primary (all-cause mortality) and secondary endpoints (a composite of all-cause mortality and heart failure rehospitalization) in Kaplan–Meier analyses (log-rank test, P < 0.001). Multivariable Cox proportional hazards models showed that the score was significantly independently associated with both primary and secondary endpoints after adjusted by covariates ( P < 0.001). Conclusion: We validated the risk prediction ability of ACUTE HF score in an Asian population. This score may be applicable in clinical practice. Highlights: The ACUTE HF score is a simple score including echocardiographic parameters. This is the first validation study for the ACUTE HF score for long-term prognosis. The ACUTE HF score is useful for risk stratification of heart failure patients. The Hosmer-Lemeshow test showed good calibration of the predicted risk.