First, do no harm: time for a systems approach to address the problem of health-care-derived pharmaceutical pollution. Issue 12 (December 2022) - Thornber, Kelly; Adshead, Fiona; Balayannis, Angeliki; Brazier, Richard; Brown, Ross; Comber, Sean; Court, Caroline; Davidson, Iain; Depledge, Michael; Farmer, Caroline; Gibb, Stuart; Hixson, Richard; et al.