Alternative polyadenylation regulation: insights from sequential polyadenylation. Issue 4 (20th October 2022)

• Record Type: Journal Article
• Authors: Tang, Peng; Zhou, Yu
• Is Part Of: Transcription. Volume 13:Issue 4/5(2022)
• Page Start: 89
• Page End: 95
• Publication Date: 2022-10-20
• Subjects: Alternative polyadenylation -- sequential polyadenylation -- regulation -- APA; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2022.2114776
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: The processing of the proximal and distal poly(A) sites in alternative polyadenylation (APA) has long been thought to independently occur on pre-mRNAs during transcription. However, a recent study by our groups demonstrated that the proximal sites for many genes could be activated sequentially following the distal ones, suggesting a multi-cleavage-same-transcript mode beyond the canonical one-cleavage-per-transcript view. Here, we review the established mechanisms for APA regulation and then discuss the additional insights into APA regulation from the perspective of sequential polyadenylation, resulting in a unified leverage model for understanding the mechanisms of regulated APA.