PARAFOVEAL INNER RETINAL THINNING AS THE BIOMARKER PREDICTING LESS RECURRENCE OF MACULAR EDEMA IN CENTRAL RETINAL VEIN OCCLUSION AFTER DISCONTINUING ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR. Issue 12 (December 2022)

• Record Type: Journal Article
• Authors: Roh, Hyeon Cheol; Lee, Geun Woo; Kang, Se Woong; Son, Ki Young; Kang, Min Chae; Choi, Kyung Jun; Kim, Sang Jin
• Is Part Of: Retina. Volume 42:Issue 12(2022)
• Page Start: 2336
• Page End: 2345
• Publication Date: 2022-12
• Subjects: antivascular endothelial growth factor -- central retinal vein occlusion -- inner retinal thinning -- macular edema; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000003616
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Parafoveal inner retinal thinning after resolution of macular edema by antivascular endothelial growth factor treatment was predictive of a lower risk of recurrence of macular edema in central retinal vein occlusion. Abstract : Purpose: To identify the predictive factors for the recurrence of macular edema after the cessation of antivascular endothelial growth factor treatment in eyes with central retinal vein occlusion (CRVO). Methods: This retrospective study included participants who had discontinued intravitreal bevacizumab injections for complete resolution of macular edema related to CRVO at 3 months after the last injection. Fifty-two eyes were enrolled in this study and classified into two groups based on the recurrence of macular edema within 1 year after the stopping point, when the decision to discontinue injections was made. Clinical characteristics and optical coherence tomographic parameters at baseline and at the stopping point were investigated. Results: Multivariate logistic regression analysis demonstrated that, at baseline, old age was associated with a significantly higher risk of macular edema recurrence (odds ratio, 1.092; P = 0.022). At the stopping point, parafoveal inner retinal thickness (odds ratio: 1.043, P = 0.014) and the presence of ellipsoid zone disruption (odds ratio: 5.922, P = 0.032) were predictive factors for recurrence. The receiver operating characteristic curve showed that parafoveal inner retinal thinning of >7 µ m compared with that in the fellow eye was significantly associated with decreased recurrence of macular edema. Conclusion: Parafoveal inner retinal thinning and intact ellipsoid zone after resolution of macular edema by antivascular endothelial growth factor treatment were predictive of a lower risk of recurrence of macular edema in CRVO. These intuitive biomarkers may help predict future disease courses and design optimal treatment strategies.