Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia. Issue 11 (1st February 2021)

• Record Type: Journal Article
• Authors: Rico, Angelica; Dollard, Sheila C.; Valencia, Diana; Corchuelo, Sheryll; Tong, Van T.; Laiton‐Donato, Katherine; Amin, Minal M.; Benavides, Monica; Wong, Phili; Newton, Suzanne; Daza, Marcela; Cates, Jordan; Gonzalez, Maritza; Zambrano, Laura D.; Mercado, Marcela M.; Ailes, Elizabeth C.; Rodriguez, Helena M.; Gilboa, Suzanne M.; Acosta, Jacqueline; Ricaldi, Jessica; Pelaez, Dioselina; Honein, Margaret A.; Ospina, Martha L.; Lanzieri, Tatiana M.
• Is Part Of: Journal of medical virology. Volume 93:Issue 11(2021)
• Page Start: 6393
• Page End: 6397
• Publication Date: 2021-02-01
• Subjects: CMV -- Colombia -- congenital infection -- cytomegalovirus -- newborns -- postnatal infection -- prevalence -- seroprevalence; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.26815
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8–12) weeks gestation ( n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%–98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%–18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%–59.1%) had postnatal infection. Highlights: In this multi‐city study in Colombia, maternal CMV seroprevalence was 98.1%, the prevalence of congenital CMV infection was 8.4 per 1000 live births, and 54.7% of infants had postnatal infection by 6 months of age.