A Nanoscale Metal–Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy. Issue 3 (29th November 2019)

• Record Type: Journal Article
• Authors: Ni, Kaiyuan; Luo, Taokun; Lan, Guangxu; Culbert, August; Song, Yang; Wu, Tong; Jiang, Xiaomin; Lin, Wenbin
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 3(2020)
• Page Start: 1108
• Page End: 1112
• Publication Date: 2019-11-29
• Subjects: antigen presentation -- checkpoint blockade immunotherapy -- CpG delivery -- metal–organic frameworks -- photodynamic therapy; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201911429
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Checkpoint blockade immunotherapy (CBI) awakes a host innate immune system and reactivates cytotoxic T cells to elicit durable response in some cancer patients. Now, a cationic nanoscale metal–organic framework, W‐TBP, is used to facilitate tumor antigen presentation by enabling immunogenic photodynamic therapy (PDT) and promoting the maturation of dendritic cells (DCs). Comprised of dinuclear W VI secondary building units and photosensitizing 5, 10, 15, 20‐tetra( p ‐benzoato)porphyrin (TBP) ligands, cationic W‐TBP mediates PDT to release tumor associated antigens and delivers immunostimulatory CpG oligodeoxynucleotides to DCs. The enhanced antigen presentation synergizes with CBI to expand and reinvigorate cytotoxic T cells, leading to superb anticancer efficacy and robust abscopal effects with >97 % tumor regression in a bilateral breast cancer model. Abstract : A metal–organic framework, W‐TBP, is used to facilitate tumor antigen presentation by enabling immunogenic photodynamic therapy (PDT) and promoting the maturation of dendritic cells (DCs). The enhanced antigen presentation synergizes with checkpoint blockade immunotherapy to expand and reinvigorate cytotoxic T cells, leading to 97 % tumor regression in a bilateral breast cancer model.