Is there an association between urine biochemical parameters on admission and the severity OF COVID‐19?. Issue 11 (18th September 2021)

• Record Type: Journal Article
• Authors: Erdogan, Omer; Ok, Fesih; Carkci, Serkan; Durmus, Emrullah
• Is Part Of: International journal of clinical practice. Volume 75:Issue 11(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-18
• Subjects: Clinical medicine -- Periodicals; Medicine -- Periodicals; 610.5
• DOI: 10.1111/ijcp.14809
• Languages: English
• ISSNs: 1368-5031

Abstract

Abstract: Aim: To determine the importance of urinary biochemical parameters on the severity of coronavirus disease‐2019 (COVID‐19). Methods: One hundred and thirty‐three patients who were diagnosed with COVID‐19 were retrospectively included. Groups were formed according to the severity of their disease (moderate [n = 85], severe [n = 29] and critical = [n = 19]), and an additional control group was created from healthy individuals (n = 50). We investigated the correlation between urine biochemical parameters and the severity of the disease. Results: Erythrocyturia, proteinuria and glucosuria rates were significantly higher in patients than in the controls. In patients, the median urine specific gravity (SG) was lower ( P < .001), and the median potential of hydrogen (pH) value was higher compared with the controls ( P < .001). In correlation analyses, there were strong positive correlations between disease severity and age ( r = 0.545, P < .001), RR ( r = 0.838, P < .001) and proteinuria ( r = 0.462, P < .001), while there was a strong negative correlation with SpO2 ( r = −0.839, P = .001). On multivariate analysis, age (OR: 1.06, 95% CI 1.03‐1.10, P = .035), respiratory rate ≥30 breaths/min (OR: 4.72, 95% CI 1.26‐6.24, P < .0031), SpO2 ≤ 93% (OR: 3.82, 95% CI 1.18‐5.82, P = .001) and proteinuria (OR: 1.13, 95%CI 1.02‐2.1, P = .023) were independent predictive factors for disease severity. Conclusion: Proteinuria in routine urine analysis, which is one of the parameters that can be easily applied in the application, may be related to the severity of the COVID‐19 disease.