Fluorescence Sensing of Glutathione Thiyl Radical by BODIPY‐Modified β‐Cyclodextrin. Issue 4 (24th December 2021)

• Record Type: Journal Article
• Authors: Liu, Zhixue; Dai, Xianyin; Xu, Qiaoyan; Sun, Xiaohan; Liu, Yu
• Is Part Of: Chinese journal of chemistry. Volume 40:Issue 4(2022)
• Page Start: 493
• Page End: 499
• Publication Date: 2021-12-24
• Subjects: Cyclodextrins -- Glutathione thiyl radical -- Biosensors -- BODIPY -- Radical reaction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.202100662
• Languages: English
• ISSNs: 1001-604X

Abstract

Comprehensive Summary: The fluorescence sensing of intracellular glutathione thiyl radical (GS) is in great demand to seek the GS‐related pathophysiological events. Herein, boron−dipyrromethene (BODIPY)‐modified β‐cyclodextrin was developed for high‐efficiency sensing of GS, accompanied by a fast response time ( t 1/2 = 218 s), with the detection limit of 468 nmol/L. Cell experiments indicated that the BODIPY‐ modified β‐cyclodextrin could be applied to detect the GS in live A549 cells. Abstract : A unique ratiometric fluorescent probe was developed by BODIPY‐modified β‐cyclodextrin based on cross‐coupling reaction between thiol radicals and BODIPY. The probe not only shows good water solubility and biocompatibility, but also enables high‐sensitive detecting of glutathione thiyl radical in cancer cells.