Antireflux metal stent for biliary obstruction: Any benefits?. Issue 3 (16th June 2020)

• Record Type: Journal Article
• Authors: Hamada, Tsuyoshi; Nakai, Yousuke; Isayama, Hiroyuki; Koike, Kazuhiko
• Is Part Of: Digestive endoscopy. Volume 33:Issue 3(2021)
• Page Start: 310
• Page End: 320
• Publication Date: 2020-06-16
• Subjects: common bile duct -- endoscopic retrograde cholangiopancreatography -- extrahepatic cholestasis -- randomized controlled trial -- stents; Digestive organs -- Diseases -- Periodicals; Digestive organs -- Diseases -- Diagnosis -- Periodicals; Endoscopy -- Periodicals; Digestive System Diseases -- diagnosis -- Periodicals; Digestive System Diseases -- therapy -- Periodicals; Endoscopy -- Periodicals; 616.3
• DOI: 10.1111/den.13679
• Languages: English
• ISSNs: 0915-5635

Abstract

Abstract : Endoscopic retrograde cholangiopancreatography with stent placement has been utilized as standard palliative management of distal malignant biliary obstruction (MBO). Compared to plastic stents, metal stents can provide longer‐term relief of symptoms. When a large‐bore metal stent is placed across the ampulla, patients are predisposed to the risk of cholangitis or stent dysfunction due to reflux of duodenal contents. To mitigate the risk of adverse events associated with the duodenobiliary reflux, efforts have been directed to development of antireflux metal stents (ARMSs). The antireflux property has been introduced through adding of an antireflux valve to the duodenal stent end. Evidence from clinical studies indicates that ARMSs may not only reduce the risk of ascending cholangitis during follow‐up but also prolong stent patency time. However, the results of clinical studies testing ARMSs are inconsistent owing to heterogeneous designs of antireflux valves and stent bodies. Metal stents are increasingly indicated for benign biliary strictures and MBO in the setting of neoadjuvant chemotherapy, and therefore, research is warranted to evaluate ARMSs for those indications. Given that endoscopic ultrasound (EUS)‐guided transmural biliary drainage has gained popularity, the optimal timing of placing an ARMS in relation to EUS‐guided and percutaneous drainage should be investigated. Development and evaluation of ARMSs require an integrative approach utilizing phantom and animal models, measurements of stent mechanical properties, and in vivo functional study after stent placement. In this review article, we summarize updated evidence on ARMSs for MBO and discuss issues that should be addressed in future studies.