Predominance of norovirus GI.4 from children with acute gastroenteritis in Jambi, Indonesia, 2019. Issue 12 (9th June 2020)

• Record Type: Journal Article
• Authors: Wulandari, Putri Sari; Juniastuti, ; Wahyuni, Rury Mega; Amin, Mochamad; Yamani, Laura Navika; Matondang, Muhammad Qushai Yunifiar; Dinana, Zayyin; Soetjipto, ; Utsumi, Takako; Shoji, Ikuo; Lusida, Maria Inge
• Is Part Of: Journal of medical virology. Volume 92:Issue 12(2020)
• Page Start: 3165
• Page End: 3172
• Publication Date: 2020-06-09
• Subjects: acute gastroenteritis -- genogroup -- genotype -- Indonesia -- norovirus; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.26057
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: Norovirus (NoV) is one of the most important viral causes of acute gastroenteritis (AGE) in children worldwide. Only a few studies have reported AGE with NoV‐positive in some cities in Indonesia. This study aimed to investigate the incidence and clinical characteristic of NoV infection, and also genotype distribution of NoV in children with AGE in Jambi, as the capital and the largest city of Jambi province, Indonesia. Stool samples were collected from children (≤15 years of age) with AGE at three participating hospitals in Jambi from February to April 2019. The detection of NoV and its genotyping were carried out by reverse‐transcriptase polymerase chain reaction and direct sequencing. Of the 91 stool samples collected, 14 (15.4%) were positive for NoV. Fever, vomiting, and severe diarrhea were commonly observed in AGE with NoV, while level of dehydration was statistically significant difference between children with NoV‐positive and those with NoV‐negative. The most prevalent genotype was GI.4 (42.9%), followed by GII.6 (28.6%) and some other genotypes. Interestingly, this study found the predominance of GI.4, differed from previous reports in Indonesia. Continuously investigation of the circulating genotype is needed to control the NoV‐infected AGE.