Intracranial Sensors for Continuous Monitoring of Neurophysiology. Issue 12 (24th August 2021)

• Record Type: Journal Article
• Authors: Jiang, Nan; Flyax, Sergey; Kurz, Wolfgang; Jakobi, Martin; Tasoglu, Savas; Koch, Alexander W.; Yetisen, Ali K.
• Is Part Of: Advanced materials technologies. Volume 6:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-24
• Subjects: brain monitoring -- electrochemical sensors -- fiber‐optic sensors -- intracranial sensors -- microdialysis; Materials science -- Periodicals; Technological innovations -- Periodicals; Materials science; Technological innovations; Periodicals; 620.1105
• DOI: 10.1002/admt.202100339
• Languages: English
• ISSNs: 2365-709X

Abstract

Abstract: Monitoring physiological parameters in the brain is important to identify early signs of secondary brain injuries. A variety of different intracranial sensors enable continuous monitoring of important brain parameters in clinical applications. However, many of the clinically approved and established technologies show drawbacks in zero‐drift properties, accuracy and magnet resonance imaging (MRI) compatibility. This review gives a comparative overview of the established technologies and provides an outlook on fiber‐optic sensors (FOS) with potential use in future intracranial monitoring applications. Neurophysiological parameters recorded by bioelectrical signals include intracranial pressure (ICP), brain temperature, brain tissue oxygenation, cerebral blood flow, and cerebral metabolism. The comparison of ICP sensors revealed that piezoresistive strain gauge sensors provide the highest accuracy and the smallest zero‐drift in clinical catheters. Fiber‐optic pressure sensors show a potential to be used in future intracranial applications. Thermistors and thermocouples prove to be reliable for temperature measurement in intracranial catheters, but have limited MRI compatibility. FOS show potential to be used in future intracranial catheters for temperature and oxygen measurement, as they provide higher accuracy and a better response time. Microdialysis catheters, in combination with new automated electrochemical and optical analyzers, provide the possibility of routine metabolism monitoring in clinics. Abstract : Detection of different physiological parameters in the brain is essential to early diagnosis and monitoring of brain diseases or injuries. This article reviews the established and ongoing technologies of optical biosensors that could be used in brain monitoring including intracranial pressure, brain temperature, oxygen level, cerebral blood flow, and cerebral metabolism.