Importance of NT-proBNP and conventional risk factors for prediction of death in older adults with and without diabetes mellitus– A report from the Atherosclerosis Risk in Communities (ARIC) study. (December 2022)

• Record Type: Journal Article
• Authors: Wijkman, Magnus O.; Claggett, Brian L.; Malachias, Marcus V.B.; Vaduganathan, Muthiah; Ballantyne, Christie M.; Kitzman, Dalane W.; Mosley, Thomas; Matsushita, Kunihiro; Solomon, Scott D.; Pfeffer, Marc A.
• Is Part Of: Diabetes research and clinical practice. Volume 194(2022)
• Publication Date: 2022-12
• Subjects: Diabetes mellitus -- Biomarkers -- B-type natriuretic peptide -- Risk prediction -- Mortality -- Epidemiology; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2022.110164
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: NT-proBNP as a single biomarker predicted all-cause death in older adults. In those without diabetes, NT-proBNP discriminated similarly as the PCE variables. In those with diabetes, NT-proBNP discriminated better than the PCE variables. Abstract: In this community-based cohort of 5861 individuals followed for median 7.2 years, the discriminatory ability of NT-proBNP alone in predicting mortality was similar to that of multiple conventional markers of risk in people without diabetes. In people with diabetes, NT-proBNP alone discriminated risk of mortality better than conventional risk factors.