The emerging role of immunotherapy in the treatment of anal cancer. (December 2022)

• Record Type: Journal Article
• Authors: Saúde-Conde, Rita; Parisi, Alessandro; Giunta, Emilio Francesco; Meyers, Michel; Sclafani, Francesco
• Is Part Of: Current opinion in pharmacology. Volume 67(2022)
• Publication Date: 2022-12
• Subjects: Pharmacology -- Periodicals; Pharmaceutical Preparations -- Periodicals; Drug Therapy -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Periodicals; 615.105
• DOI: 10.1016/j.coph.2022.102309
• Languages: English
• ISSNs: 1471-4892

Abstract

Abstract: For decades, chemoradiotherapy for early-stage disease and systemic chemotherapy for advanced disease have represented the mainstay of treatment for anal cancer. Over the last few years, however, the advent of immunotherapy has opened interesting therapeutic perspectives, with the establishment of new standards of care, and the development of clinical trials that may further shape the treatment algorithm for this tumour. In this review article, we discuss the rationale behind the use of immunotherapy for anal cancer and provide an overview of the available clinical data and ongoing efforts to build on these.