Acute myeloid leukemia with variant t(8;10;21). (2022)

• Record Type: Journal Article
• Authors: Bacova, Barbora; Sobotka, Jiri; Kacirkova, Petra; Rivnacova, Veronika; Karlova/Zubata, Ivana; Novak, Jan
• Is Part Of: Leukemia research reports. Volume 18(2022)
• Publication Date: 2022
• Subjects: Acute myeloid leukemia -- Cytogenetics -- Fluorescence in situ hybridization -- t(8 -- 21); Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2022.100350
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3–4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;21) AML with mutated c-KIT that shared key morphological features with classical t(8;21) leukemias, including the M2 morphology pattern and CD34, HLA-DR phenotype. The 63-year-old female was treated with two inductioncontaining Daunoribicine and Cytarabine and four cycles of intermediate-dose Cytarabine (1.5 g/m 2 ) and achieved long-lasting remission.