Impact of endorectal filling on interobserver variability of MRI based rectal primary tumor delineation. (January 2023)

• Record Type: Journal Article
• Authors: Lo Russo, Monica; Nachbar, Marcel; Barry, Aisling; Bhide, Shree; Chang, Amy; Hall, William; Intven, Martijn; Marijnen, Corrie; Peters, Femke; Minsky, Bruce; Romesser, Paul B.; Sarkar, Reith; Tan, Alex; Boeke, Simon; Wegener, Daniel; Butzer, Sarah; Boldt, Jessica; Gatidis, Sergios; Nikolaou, Konstantin; Thorwarth, Daniela; Zips, Daniel; Gani, Cihan
• Is Part Of: Clinical and translational radiation oncology. Volume 38(2023)
• Page Start: 1
• Page End: 5
• Publication Date: 2023-01
• Subjects: Rectal cancer -- MR-guided radiotherapy -- MRI-Linac -- Inter-observer agreement; Cancer -- Radiotherapy -- Periodicals; Oncology -- Periodicals; Cancer -- Radiotherapy; Oncology; Radiation Oncology; Neoplasms -- radiotherapy; Translational Medical Research; Periodicals; Electronic journals; Periodicals; 616.9940642
• DOI: 10.1016/j.ctro.2022.09.002
• Languages: English
• ISSNs: 2405-6308

Abstract

Highlights: Interobserver variability of MRI based primary tumor delineation studied by a panel of international experts. Interobserver variability significantly improves after the application of 100 cc of rectal ultrasound gel. The approach presented possibly improved dose escalation protocols in rectal cancer. Abstract: Background: Online adaptive MR-guided radiotherapy allows for the reduction of safety margins in dose escalated treatment of rectal tumors. With the use of smaller margins, precise tumor delineation becomes more critical. In the present study we investigated the impact of rectal ultrasound gel filling on interobserver variability in delineation of primary rectal tumor volumes. Methods: Six patients with locally advanced rectal cancer were scanned on a 1.5 T MRI-Linac without (MRI_e) and with application of 100 cc of ultrasound gel transanally (MRI_f). Eight international radiation oncologists expert in the treatment of gastrointestinal cancers delineated the gross tumor volume (GTV) on both MRI scans. MRI_f scans were provided to the participating centers after MRI_e scans had been returned. Interobserver variability was analyzed by either comparing the observers' delineations with a reference delineation (approach 1) and by building all possible pairs between observers (approach 2). Dice Similarity Index (DICE) and 95 % Hausdorff-Distance (95 %HD) were calculated. Results: Rectal ultrasound gel filling was well tolerated by all patients. Overall, interobserver agreement was superior in MRI_f scans based on median DICE (0.81 vs 0.74, p < 0.005 for approach 1 and 0.76 vs 0.64, p < 0.0001 for approach 2) and 95 %HD (6.9 mm vs 4.2 mm for approach 1, p = 0.04 and 8.9 mm vs 6.1 mm, p = 0.04 for approach 2). Delineated median tumor volumes and inter-quartile ranges were 26.99 cc [18.01–50.34 cc] in MRI_e and 44.20 [19.72–61.59 cc] in MRI_f scans respectively, p = 0.012. Conclusions: Although limited by the small number of patients, in this study the application of rectal ultrasound gel resulted in higher interobserver agreement in rectal GTV delineation. The endorectal gel filling might be a useful tool for future dose escalation strategies.