Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing. (December 2022)

• Record Type: Journal Article
• Authors: Haraguchi, Atsushi; Yamazaki, Tomohiro; Ryan, Conn; Ito, Kaede; Sato, Shuhei; Tamura, Konomi; Sekiguchi, Masataka; Cao, Siyuan; Shibata, Shigenobu
• Is Part Of: Journal of functional foods. Volume 99(2022)
• Publication Date: 2022-12
• Subjects: Anti-obesity effect -- Caffeine -- Chrono-nutrition -- Circadian clock system -- Lipogenesis; BF breakfast -- Bmal1 brain and muscle Arnt-like protein 1 -- Clock circadian locomoter output cycles kaput -- CM mice clock-mutant mice -- DN dinner -- EE energy expenditure -- EGCG (−)-epigallocatechin-3-gallate -- FDR false discovery rate -- HDL cholesterol high-density lipoprotein cholesterol -- HFD high-fat diet -- HFD-caf high-fat diet supplemented with 0.03% caffeine -- HMG hydroxymethylglutaryl -- ICR mice institute of cancer research mice -- LDL cholesterol low-density lipoprotein cholesterol -- TRF time-restricted feeding -- PDE phosphodiesterase -- Per1/2 Period1/2 -- RER respiratory exchange ratio -- RT–PCR reverse transcription–polymerase chain reaction -- SCN suprachiasmatic nucleus -- SEM standard error of mean -- WT wildtype -- ZT Zeitgeber time; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.105307
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Effects of caffeine would vary depending on timing of intake. Caffeine at the begging of active period would inhibit weight by high-fat diet. Caffeine at the begging of active period would enhance clock gene expression rhythms. Caffeine at the begging of active period would suppress lipogenesis genes expression. Abstract: The time-dependent effects of caffeine intake on physiological functions remain to be investigated, although various effects of caffeine on physiological functions have been document. Therefore, the present study investigated the optimal timing of caffeine intake to produce an efficient anti-obesity effect. We prepared a high-fat diet (HFD) or HFD supplemented with 0.03% caffeine (HFD-caf) and regulated twice-daily 8-hour time-restricted feeding. Male Institute of Cancer Research mice were divided into three groups: group fed HFD alone (control), group fed HFD-caf at the beginning of the active period (BF-caf), and group fed HFD-caf at the end of the active period (DN-caf). The BF-caf group (42.8 ± 1.5 g) showed lower body weight than the other groups (control, 49.7 ± 2.1 g; DN-caf, 47.1 ± 1.3 g), although the three groups showed similar HFD intake levels. Therefore, caffeine intake at the beginning of the active period suppressed HFD-induced body weight gain.