Feasibility study of 2D Dixon-Magnetic Resonance Fingerprinting (MRF) of breast cancer. (2022)

• Record Type: Journal Article
• Authors: Zanderigo, Eloisa; Huck, Luisa; Distelmaier, Martina; Dethlefsen, Ebba; Maywald, Mirjam; Truhn, Daniel; Dirrichs, Timm; Doneva, Mariya; Schulz, Volkmar; Kuhl, Christiane K.; Nolte, Teresa
• Is Part Of: European journal of radiology open. Volume 9(2022)
• Publication Date: 2022
• Subjects: Breast diagnostic -- Breast cancer -- Magnetic resonance imaging -- Quantitative MRI -- Magnetic Resonance Fingerprinting; Medical radiology -- Periodicals; 616.075705
• DOI: 10.1016/j.ejro.2022.100453
• Languages: English
• ISSNs: 2352-0477

Abstract

Abstract: Purpose: Application of MRF to evaluate the feasibility of 2D Dixon blurring-corrected MRF (2DDb-cMRF) to differentiate breast cancer (BC) from normal fibroglandular tissue (FGT). Methods: Prospective study on 14 patients with unilateral BC on 1.5 T system/axial T2w-TSE sequence, 2DDb-cMRF, B1 map, dynamic contrast-enhanced (DCE) T1-w GE-series. Mean T1 and T2 values and standard deviations were computed in the BC-/FGT-ROI on pre-/post-contrast MRF-maps and their differences were tested by two-tailed student t-test. Accuracy and repeatability of MRF were evaluated in a phantom experiment with gelatin with Primovist surrounded by fat. The T1 reduction between pre-/post-contrast MRF-maps was correlated to DCE signal enhancement in the last image post-contrast through the Pearson´s correlation coefficient (r) and for the phantom validation experiment through the Lin's concordance correlation coefficient (CCC). Visual evaluation of cancers on MRF-Maps was performed by rating each MRF-Map by 3 radiologists. Results: T1- and T2-MRF values of BC vs. FGT were for T1 and T2 pre-contrast respectively: 1147 ± 1 ms vs. 1052 ± 9 ms (p = 0.007) and 83 ± 1 ms vs. 73 ± 1 ms (p = 0.03); post-contrast respectively: 367.3 ± 121.5 ms vs. 690.3 ± 200.3 ms (p = 0.0005) and 76.9 ± 11.5 ms vs. 69.8 ± 15.2 ms (p = 0.12). r was positive (FGT r = 0.7; BC r = 0.6). CCC was 0.999 for T1 and 0.994 for T2. In the T1- and T2-MRF-Maps before contrast respectively (7, 7, 8)/14 and (5, 9, 8)/14 cancers were visible to the readers; afterwards, (11, 12, 12)/14 and (5, 6, 11)/14. Conclusions: MRF is promising for distinction between BC and FGT as well as for analyzing pre-/post-contrast T1 changes. However, its potential for differential diagnosis warrants further studies.