Resolving inflammatory links between myocardial infarction and vascular dementia. (January 2022)

• Record Type: Journal Article
• Authors: Thorp, Edward B.; Flanagan, Margaret E.; Popko, Brian; DeBerge, Matthew
• Is Part Of: Seminars in immunology. Volume 59(2022)
• Publication Date: 2022-01
• Subjects: Myocardial infarction -- Vascular dementia; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2022.101600
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Myocardial infarction is associated with increased risk for vascular dementia. In both myocardial infarction and vascular dementia, there is evidence that elevated inflammatory biomarkers are associated with worsened clinical outcomes. Myocardial infarction leads to a systemic inflammatory response, which may contribute to recruitment or activation of myeloid cells, including monocytes, microglia, and perivascular macrophages, within the central nervous system. However, our understanding of the causative roles for these cells linking cardiac injury to the development and progression of dementia is incomplete. Herein, we provide an overview of inflammatory cellular and molecular links between myocardial infarction and vascular dementia and discuss strategies to resolve inflammation after myocardial infarction to limit neurovascular injury.