Recent advances in one-dimensional nanowire-incorporated bone tissue engineering scaffolds. (December 2022)

• Record Type: Journal Article
• Authors: Lavanya, K.; Abinaya, S.; Selvamurugan, N.
• Is Part Of: Materials today communications. Volume 33(2022)
• Publication Date: 2022-12
• Subjects: 3D Three dimensional -- 1D One dimensional -- Alg Alginate -- ALP Alkaline Phosphatase -- BMSCs Bone Marrow Stromal Cells -- BMP Bone Morphogenetic Protein -- BG Bioactive Glass/Bioglass -- BSA Bovine Serum Albumin -- BTE Bone Tissue engineering -- CaP Calcium Phosphate -- Col Collagen -- CS Chitosan -- ECM Extra Cellular Matrix -- FGF Fibroblast Growth Factor -- Gel Gelatin -- GO Graphene oxide -- HAp Hydroxyapatite -- MSC Mesenchymal Stem Cell -- MRSA Methicillin-resistant Staphylococcus aureus -- NP Nanoparticle -- NWs Nanowires/Nanowhiskers -- OCN Osteocalcin -- OPN Osteopontin -- PHBV Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) -- PEUR Poly (ester urethane) -- PCL Poly Caprolactone -- PLA Poly lactic acid -- PLGA Poly (lactic-co-glycolic acid) -- PLLA Poly-L-Lactic Acid -- PVP Polyvinyl Pyrrolidone -- SF Silk fibroin -- TiO 2 Titanium Oxide -- TCP Tricalcium Phosphate -- TGF-β Transforming Growth Factor- β -- VEGF Vascular Endothelial Growth Factor -- UHANWs Ultralong Hydroxyapatite -- BMD Bone mineral density -- GELMA Gelatin methacryloyl -- rBMSCs Rat bone marrow stem cells -- mBMSCs Mouse mesenchymal stem cells -- GBR Guided bone regeneration -- CSH calcium silicate hydrate -- Si Silicon -- Sr Strontium -- ADSCs adipose-derived stem cells -- Ti Titanate or titanium -- WH Whitlockite -- RANKL Receptor activator of nuclear factor kappa-Β ligand -- CaSiO3 Calcium silicate -- Ca Calcium -- P Phosphate -- FAK Focal adhesion kinase -- PBSU poly (butylene succinate) -- WS Wollastonite -- Tb Terbium -- Zn Zinc -- Ag Silver -- PP Polypyrrole; Bone tissue engineering -- Polymers -- Bioceramics -- Nanowires -- Stem cells -- Charged ions transfer; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2022.104229
• Languages: English
• ISSNs: 2352-4928

Abstract

Abstract: Several million people worldwide have become witnesses of orthopedic ailments every year, resulting in an urgent need to develop biomimetic bone grafts. The bone's ability to self-heal is limited in critical-sized bone defects, which remains a massive obstacle. Bone tissue engineering (BTE) is a promising approach that could mitigate the risks associated with the conventional gold standard methods. Regardless of the advancement of several biomaterials, nanomaterials have received tremendous attention in recent decades for their potential use as a smart graft material for creating a hierarchical bone structure. Amongst the myriad nanostructures, nanowires/nanowhiskers (NWs) have emerged as ideal cutting-edge materials for accelerating bone rehabilitation due to their unique physicochemical properties such as high surface-to-volume ratio, multi-absorbing sites, high reactivity, and more amenable surface topography. This review explores recent developments on bone mineral, metal/metal oxide, and polymer-based NW constructs for BTE applications. Graphical Abstract: Nanowires-based bone constructs: The activation of intracellular and extracellular signaling cascades by ions released from the nanowires allows stem cell differentiation towards osteoblast for bone regeneration. ga1