Clinical and economic burden of pneumococcal disease among individuals aged 16 years and older in Germany. (8th November 2022)

• Record Type: Journal Article
• Authors: Deb, Arijita; Podmore, Bélène; Barnett, Rosemarie; Beier, Dominik; Galetzka, Wolfgang; Qizilbash, Nawab; Haeckl, Dennis; Mihm, Sarah; Johnson, Kelly D.; Weiss, Thomas
• Is Part Of: Epidemiology and infection. Volume 150(2022)
• Publication Date: 2022-11-08
• Subjects: All-cause pneumonia -- claims data -- Germany -- healthcare resource utilisation -- invasive pneumococcal disease; Communicable diseases -- Periodicals; Epidemiology -- Periodicals; 614.4
• DOI: 10.1017/S0950268822001182
• Languages: English
• ISSNs: 0950-2688

Abstract

Abstract: This study assessed the incidence rate of all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD) and associated medical costs among individuals aged ≥16 in the German InGef database from 2016 to 2019. Incidence rate was expressed as the number of episodes per 100 000 person-years (PY). Healthcare resource utilisation was investigated by age group and by risk group (healthy, at-risk, high-risk). Direct medical costs per ACP/IPD episode were estimated as the total costs of all inpatient and outpatient visits. The overall incidence rate of ACP was 1345 (95% CI 1339–1352) and 8.25 (95% CI 7.76–8.77) per 100 000 PY for IPD. For both ACP and IPD, incidence rates increased with age and were higher in the high-risk and at-risk groups, in comparison to the healthy group. ACP inpatient admission rate increased with age but remained steady across age-groups for IPD. The mean direct medical costs per episode were €8075 (95% CI 7121–9028) for IPD and €1454 (95% CI 1426–1482) for ACP. The aggregate direct medical costs for IPD and ACP episodes were estimated to be €8.5 million and €248.9 million respectively. The clinical and economic burden of IPD and ACP among German adults is substantial regardless of age.