Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients. Issue 12 (24th September 2022)

• Record Type: Journal Article
• Authors: Pham, Truong‐Thanh; Andrey, Diego O.; Stampf, Susanne; Burkhard, Sara H.; Hirzel, Cédric; Tschopp, Johnathan; Ullrich, Kathrin; Strahm, Carol; Schreiber, Peter W.; Boillat‐Blanco, Noémie; Garzoni, Christian; Khanna, Nina; Manuel, Oriol; Mueller, Nicolas J.; Suva, Domizio; van Delden, Christian; Uçkay, Ilker; Neofytos, Dionysios
• Other Names: Amico Patrizia investigator.; Axel Andres investigator.; Aubert John‐David investigator.; Banz Vanessa investigator.; Beckmann Sonja investigator.; Beldi Guido investigator.; Berger Christoph investigator.; Berishvili Ekaterine investigator.; Berzigotti Annalisa investigator.; Binet Isabelle investigator.; Bochud Pierre‐Yves investigator.; Branca Sanda investigator.; Bucher Heiner investigator.; Catana Emmanuelle investigator.; Cairoli Anne investigator.; Chalandon Yves investigator.; De Geest Sabina investigator.; De Rougemont Olivier investigator.; De Seigneux Sophie investigator.; Dickenmann Michael investigator.; Dreifuss Joëlle Lynn investigator.; Duchosal Michel investigator.; Fehr Thomas investigator.; Ferrari‐Lacraz Sylvie investigator.; Golshayan Déla investigator.; Goossens Nicolas investigator.; Halter Jörg investigator.; Heim Dominik investigator.; Hess Christoph investigator.; Hillinger Sven investigator.; Hirsch Hans H. investigator.; Hirt Patricia investigator.; Hofbauer Günther investigator.; Huynh‐Do Uyen investigator.; Immer Franz investigator.; Koller Michael investigator.; Laager Mirjam investigator.; Laesser Bettina investigator.; Lamoth Frédéric investigator.; Lehmann Roger investigator.; Leichtle Alexander investigator.; Marti Hans‐Peter investigator.; Martinelli Michele investigator.; McLin Valérie investigator.; Mellac Katell investigator.; Merçay Aurélia investigator.; Mettler Karin investigator.; Müller Antonia investigator.; Müller‐Arndt Ulrike investigator.; Müllhaupt Beat investigator.; Nägeli Mirjam investigator.; Oldani Graziano investigator.; Pascual Manuel investigator.; Passweg Jakob investigator.; Pazeller Rosemarie investigator.; Posfay‐Barbe Klara investigator.; Rick Juliane investigator.; Rosselet Anne investigator.; Rossi Simona investigator.; Rothlin Silvia investigator.; Ruschitzka Frank investigator.; Schachtner Thomas investigator.; Schanz Urs investigator.; Schaub Stefan investigator.; Scherrer Alexandra investigator.; Schnyder Aurelia investigator.; Schuurmans Macé investigator.; Schwab Simon investigator.; Sengstag Thierry investigator.; Simonetta Federico investigator.; Steiger Jürg investigator.; Stirnimann Guido investigator.; Stürzinger Ueli investigator.; Venetz Jean‐Pierre investigator.; Villard Jean investigator.; Vionnet Julien investigator.; Wick Madeleine investigator.; Wilhelm Markus investigator.; Yerly Patrick investigator.;
• Is Part Of: American journal of transplantation. Volume 22:Issue 12(2022)
• Page Start: 3031
• Page End: 3046
• Publication Date: 2022-09-24
• Subjects: BJI -- bone and joint infection -- epidemiology -- solid organ transplant recipients; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.17184
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Bone and joint infection (BJI) epidemiology and outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI in a multi‐center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive SOTr with BJI (01.05.2008–31.12.2019) were included. A nested case–control study to identify risk factors for BJI was performed. Among 4482 patients, 61 SOTr with 82 BJI were included, at an incidence of 1.4% (95% CI 1.1–1.7), higher in heart and kidney‐pancreas SOTr (Gray's test p < .01). Although BJI were predominately late events (median of 18.5 months post‐SOT), most infections occurred during the first year post‐transplant in thoracic SOTr. Diabetic foot osteomyelitis was the most frequent infection (38/82, 46.3%), followed by non‐vertebral osteomyelitis (26/82, 31.7%). Pathogens included Gram‐positive cocci (70/131, 53.4%), Gram‐negative bacilli (34/131, 26.0%), and fungi (9/131, 6.9%). BJI predictors included male gender (OR 2.94, 95% CI 1.26–6.89) and diabetes (OR 2.97, 95% CI 1.34–6.56). Treatment failure was observed in 25.9% (21/81) patients and 1‐year mortality post‐BJI diagnosis was 14.8% (9/61). BJI remain a rare event in SOTr, associated with subtle clinical presentations, high morbidity and relapses, requiring additional studies in the future. Abstract : In solid organ transplant recipients, bone and joint infections, rare complications with subtle clinical presentation, high morbidity and frequent relapse, require special attention from treating physicians.