Severe hyperferremia and hyperferritinemia in a dog with precursor‐directed immune‐mediated anemia. (16th May 2022)

• Record Type: Journal Article
• Authors: Zersen, Kristin M.; Gregory, Carly W.; Jeffries, Christina M.; Olver, Christine
• Is Part Of: Veterinary clinical pathology. Volume 51:Number 4(2022)
• Page Start: 491
• Page End: 494
• Publication Date: 2022-05-16
• Subjects: ferritin -- iron -- nonregenerative anemia; Veterinary pathology -- Periodicals; 636.089607
• DOI: 10.1111/vcp.13130
• Languages: English
• ISSNs: 0275-6382

Abstract

Abstract: A 4‐year‐old dog was evaluated at the Colorado State University Veterinary Teaching Hospital for lethargy and hyporexia of 24 hours duration. On presentation, she had a marked normocytic, normochromic, nonregenerative anemia (HCT 14%; RI 40–55). Her serum iron concentration (1651 μg/dL; RI 73–245) and serum ferritin concentration (1337 ng/mL; RI 89–489) were markedly elevated. Bone marrow aspirate and core biopsy were consistent with a diagnosis of precursor‐directed immune‐mediate anemia. To the authors' knowledge, these are the highest reported serum iron and ferritin concentrations in a patient with precursor‐directed immune‐mediate anemia. The iron concentration improved significantly after treatment, supporting the theory that the hyperferremia was due to hemolysis and ineffective erythropoiesis.