Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report. Issue 5 (9th May 2019)

• Record Type: Journal Article
• Authors: McDonald, Vanessa M.; Fingleton, James; Agusti, Alvar; Hiles, Sarah A.; Clark, Vanessa L.; Holland, Anne E.; Marks, Guy B.; Bardin, Philip P.; Beasley, Richard; Pavord, Ian D.; Wark, Peter A.B.; Gibson, Peter G.
• Other Names: author non-byline.; Agusti Alvar author non-byline.; Anderson Gary author non-byline.; Bardin Philip P. author non-byline.; Beasley Richard author non-byline.; Cheng Allen author non-byline.; Chung Li Ping author non-byline.; Clark Vanessa L. author non-byline.; Dabscheck Eli author non-byline.; Dharmage Shyamali author non-byline.; Fingleton James author non-byline.; Gibson Peter author non-byline.; Hardy Jo author non-byline.; Hew Mark author non-byline.; Hiles Sarah A. author non-byline.; Holland Anne E. author non-byline.; James Alan author non-byline.; Lam Krystle author non-byline.; Jayaram Lata author non-byline.; Katelaris Connie author non-byline.; Leong Paul author non-byline.; MacDonald Martin author non-byline.; Mangan Niamh author non-byline.; Marks Guy B. author non-byline.; McDonald Christine author non-byline.; McDonald Vanessa M. author non-byline.; Morgan Lucy author non-byline.; Osadnik Christian author non-byline.; Pavord Ian D. author non-byline.; Plank Maximilian author non-byline.; Roberts Mary author non-byline.; Searles Andrew author non-byline.; See Hayley author non-byline.; Spencer Aislin author non-byline.; Upham John author non-byline.; Wark Peter A.B. author non-byline.;
• Is Part Of: European respiratory journal. Volume 53:Issue 5(2019)
• Publication Date: 2019-05-09
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02058-2018
• Languages: English
• ISSNs: 0903-1936

Abstract

"Treatable traits" have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice. Treatable traits are proposed as an approach to personalised medicine for people with airway diseases. This review highlights the essential components of this approach, and how we can progress research and implementation. http://ow.ly/gV9I30nMHQ1