A Facile Structural Isomerization‐Induced 3D Spatial D‐A Interlocked Network for Achieving NIR‐II Phototheranostic Agents. Issue 50 (15th November 2022)

• Record Type: Journal Article
• Authors: Feng, Lina; Li, Chunbin; Liu, Lingxiu; Chen, Xin; Jiang, Guoyu; Wang, Jianguo; Tang, Ben Zhong
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 50(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-15
• Subjects: Molecular Packing -- NIR-II Fluorescence Imaging -- Phototheranostics -- 3D Spatial D-A Interlocked Network -- Structural Isomerization; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202212673
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The performances of second near‐infrared (NIR‐II) organic phototheranostic agents (OPTAs) depend on both molecular structure and molecular packing when used as nanoparticles (NPs). Herein, we proposed a facile structural isomerization‐induced 3D spatial donor (D)‐acceptor (A) interlocked network for achieving NIR‐II OPTAs. Two isomers, 4MNVDPP and 6MNVDPP were synthesized and formulated into NPs. 6MNVDPP, which has a larger electrostatic potential difference, exhibits a compact 3D spatial D‐A interlocked network in the crystal form, while 4MNVDPP forms 2D D‐D type J ‐aggregates. Thus, 6MNVDPP NPs show red‐shifted NIR absorption and larger molar extinction coefficient than 4MNVDPP NPs. Thanks to the typical NIR‐II emission, superior photothermal‐stability, high photothermal conversion efficiency (89 %) and reactive oxygen species production capacity, 6MNVDPP NPs exhibit outstanding NIR‐II tiny capillary vasculature/tumor imaging ability and synergistic photothermal/photodynamic anti‐cancer effect in vivo. Abstract : Second near‐infrared (NIR‐II) organic phototheranostic agents (OPTAs) were constructed based on a facile strategy of structural isomerization‐induced 3D spatial donor (D)‐acceptor (A) interlocked network packing. Outstanding NIR‐II tiny capillary vasculature/tumor imaging ability and synergistic photothermal/photodynamic anti‐cancer effect in vivo were achieved with 6MNVDPP NPs.