Of the need to reconcile discrepancies between two different reference equations for combined single-breath DLNO–DLCO in systemic sclerosis. Issue 4 (25th April 2019)

• Record Type: Journal Article
• Authors: Radtke, Thomas; Hua-Huy, Thông; Dressel, Holger; Dinh-Xuan, Anh Tuan
• Is Part Of: European respiratory journal. Volume 53:Issue 4(2019)
• Publication Date: 2019-04-25
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02109-2018
• Languages: English
• ISSNs: 0903-1936

Abstract

Systemic sclerosis (SSc) is a chronic disease of the connective tissue with an estimated prevalence of 5.8 per 100 000 in a multiethnic population living in Europe [1]. The disease mechanisms are highly complex, affecting multiple organs, including the pulmonary system. Severe pulmonary complications include SSc-associated interstitial lung disease (ILD) and pulmonary hypertension (PH), which are also associated with premature mortality [2, 3]. Early diagnosis and monitoring of pulmonary complications by spirometry, body plethysmography and pulmonary diffusing capacity are critical to lung health in SSc patients [4, 5]. This study confirms clinically relevant differences between reference equations for nitric oxide pulmonary diffusing capacity ( D LNO ) in systemic sclerosis. Future work on D LNO reference equations is required to improve the validity of D LNO outcomes. http://ow.ly/NnA030nx1vG