MEK5 promotes lung adenocarcinoma. Issue 2 (28th February 2019)

• Record Type: Journal Article
• Authors: Sánchez-Fdez, Adrián; Ortiz-Ruiz, María Jesús; Re-Louhau, María Florencia; Ramos, Isabel; Blanco-Múñez, Óscar; Ludeña, Dolores; Abad, Mar; Sánchez-Martín, Manuel; Pandiella, Atanasio; Esparís-Ogando, Azucena
• Is Part Of: European respiratory journal. Volume 53:Issue 2(2019)
• Publication Date: 2019-02-28
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01327-2018
• Languages: English
• ISSNs: 0903-1936

Abstract

Lung cancer represents the leading cause of cancer death worldwide [1]. Because of that, intense efforts are being devoted to the development of novel therapeutic strategies to fight the disease [2]. In this respect, identification of new oncogenic drivers offers therapeutic opportunities in tumours in which those molecules or other cooperating elements play a pathophysiological role. Here, we show that the MEK5 mitogen-activated protein kinase kinase has a pivotal role in lung cancer. MEK5 acts as an oncogenic driver in mice lung cancer and is pivotal for human lung adenocarcinoma http://ow.ly/M9e830mZb8N