The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency. Issue 2 (14th February 2019)

• Record Type: Journal Article
• Authors: Miravitlles, Marc; Chorostowska-Wynimko, Joanna; Ferrarotti, Ilaria; McElvaney, Noel G.; O'Hara, Karen; Stolk, Jan; Stockley, Robert A.; Turner, Alice; Wilkens, Marion; Greulich, Timm
• Other Names: author non-byline.; Greulich Timm author non-byline.; Miravitlles Marc author non-byline.; Chorostowska-Wynimko Joanna author non-byline.; Ferrarotti Ilaria author non-byline.; McElvaney Noel G. author non-byline.; O'Hara Karen author non-byline.; Stolk Jan author non-byline.; Stockley Robert A. author non-byline.; Turner Alice author non-byline.; Wilkens Marion author non-byline.; Corsico Angelo author non-byline.; Corda Luciano author non-byline.; Sucena Maria author non-byline.; Barrecheguren Miriam author non-byline.; Esquinas Cristina author non-byline.; Parr David author non-byline.; Lara Beatriz author non-byline.; Mahadeva Ravi author non-byline.; Chlumsky Jan author non-byline.; Janciauskiene Sabina author non-byline.; Bals Robert author non-byline.; Seersholm Niels author non-byline.; Kohler Malcolm author non-byline.; Clarenbach Christian author non-byline.; Altraja Alan author non-byline.; Jenssens Wim author non-byline.; Gouder Caroline author non-byline.; Hecimovic Ana author non-byline.; Dudvarski Aleksandra author non-byline.; Krams Alvils author non-byline.; Ulmeanu Ruxandra author non-byline.; Zaharie Ana author non-byline.; Mornex Jean-François author non-byline.; Yorgancioglu Arzu author non-byline.; Schmid-Scherzer Karin author non-byline.; Tanash Hanan author non-byline.; Mazulov Oleksandr author non-byline.; Ivanov Yavor author non-byline.;
• Is Part Of: European respiratory journal. Volume 53:Issue 2(2019)
• Publication Date: 2019-02-14
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00138-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

Alpha-1 antitrypsin deficiency (AATD) is a common but under-recognised genetic condition that affects approximately 1 in 2000 to 1 in 5000 individuals and predisposes to early-onset emphysema and liver disease [1]. Alpha-1 antitrypsin (AAT) is mainly produced in the liver, and its main function is to protect the lung against proteolytic damage, especially from neutrophil elastase [2]. To date, more than 100 variant alleles of the AAT gene ( SERPINA1 ) have been described, but the Z allele is the most prevalent and responsible for severe AATD leading to lung and liver disease [3]. The European Alpha-1 Research Collaboration (EARCO) will promote international research in alpha-1 antitrypsin deficiency http://ow.ly/DWwg30nwCj4