Limitations of resting haemodynamics in chronic thromboembolic disease without pulmonary hypertension. Issue 1 (17th January 2019)

• Record Type: Journal Article
• Authors: Swietlik, Emilia Maria; Ruggiero, Alessandro; Fletcher, Andrew J.; Taboada, Dolores; Knightbridge, Emily; Harlow, Louise; Harvey, Ian; Screaton, Nicholas; Cannon, John E.; Sheares, Karen K.K.; Ng, Choo; Jenkins, David P.; Pepke-Zaba, Joanna; Toshner, Mark R.
• Is Part Of: European respiratory journal. Volume 53:Issue 1(2019)
• Publication Date: 2019-01-17
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01787-2018
• Languages: English
• ISSNs: 0903-1936

Abstract

There is renewed interest in the haemodynamic definitions of pulmonary hypertension (PH), reigniting an old debate about diagnostic thresholds [1]. Recent prospective data support work dating back over 40 years demonstrating patients with "borderline" PH (mean pulmonary artery pressure (mPAP) <25 mmHg) can still have significant morbidity and mortality [2]. Therefore, lowering the mPAP threshold for the diagnosis of precapillary pulmonary arterial hypertension (PAH) has been discussed at World Symposium on Pulmonary Hypertension in Nice, France, in 2018. A potentially different approach has arisen in group 4 (chronic thromboembolic pulmonary hypertension (CTEPH)), where the concept of chronic thromboembolic disease without PH (CTED) has gained traction. Chronic thromboembolic disease (CTED) without pulmonary hypertension is emerging as a new and important disease classification http://ow.ly/ZmK730mv5Xh