Cover Feature: Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells (ChemBioChem 23/2022). (15th November 2022)

• Record Type: Journal Article
• Authors: Makarov, Dmytro; Kielkowski, Pavel
• Is Part Of: Chembiochem. Volume 23:Number 23(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-15
• Subjects: chemical proteomics -- microtubules -- neuronal differentiation -- protein modifications -- tyrosination; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202200648
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : Microtubules are dynamic structures regulated by post‐translational modifications called a tubulin code. The pictured jester's cap 'n' bells resembles disassembling microtubules—a catastrophe—with the bells illustrating the C‐terminal tyrosine on tubulins. One is replaced by our chemical proteomics probe, which is being attached by tubulin‐tyrosine ligase. The juggling amino acids of the proteins animate the tyrosination cycle. The background is a fluorescence imaging picture showing the distribution of tyrosination‐probe labelled proteins in neuroblastoma cells. More information can be found in the Research Article by D. Makarov and P. Kielkowski.