Should reversibility be assessed in all asthmatic children with normal spirometry?. Issue 2 (2nd August 2018)

• Record Type: Journal Article
• Authors: Dufetelle, Edouard; Bokov, Plamen; Delclaux, Christophe; Beydon, Nicole
• Is Part Of: European respiratory journal. Volume 52:Issue 2(2018)
• Publication Date: 2018-08-02
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00373-2018
• Languages: English
• ISSNs: 0903-1936

Abstract

Spirometry is usually normal at baseline in asthmatic children referred for pulmonary function tests (PFTs) [1]; however, a positive response to bronchodilator can be evidenced in these children [2, 3]. The detection of a significant bronchodilator response (BDR) is not meaningless as it confirms asthma and independently predicts subsequent level of forced expiratory volume in 1 s (FEV1 ) [4], response to inhaled corticosteroids [5] or correlates to increased exhaled NO [6]. In asthmatic children with normal baseline spirometry, a significant reversibility is detected in only 4.9% of cases http://ow.ly/RrBK30k9WIs