Are inhaled corticosteroids prescribed rationally in primary ciliary dyskinesia?. Issue 3 (29th March 2018)

• Record Type: Journal Article
• Authors: Dehlink, Eleonora; Richardson, Charlotte; Marsh, Gemma; Lee, Kiralie; Jamalzadeh, Angela; Bush, Andrew; Hogg, Claire; Carr, Siobhán B.
• Is Part Of: European respiratory journal. Volume 51:Issue 3(2018)
• Publication Date: 2018-03-29
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02221-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

Primary ciliary dyskinesia (PCD) is a chronic suppurative lung disease characterised by abnormal mucociliary clearance due to genetic defects of motile cilia. PCD patients often present with wheeze and many are prescribed inhaled corticosteroids (ICS). However, ICS are not recommended by international treatment guidelines unless patients have co-existing asthma or airway reactivity [1], or asthma/wheeze with reversible bronchial obstruction (BDR) [2]. The aim of this cross-sectional single-centre study was to determine whether ICS prescriptions were targeted appropriately in PCD [3]. ICS are prescribed irrationally in PCD because diagnosing airway eosinophilia and asthma in this setting is difficult http://ow.ly/nrcB30id7Be