Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea. Issue 3 (15th March 2018)

• Record Type: Journal Article
• Authors: Santamaria-Martos, Fernando; Benítez, Ivan; Girón, Cristina; Barbé, Ferran; Martínez-García, Miguel-Angel; Hernández, Luis; Montserrat, Josep M.; Nagore, Eduardo; Martorell, Antonio; Campos-Rodriguez, Francisco; Corral, Jaime; Cabriada, Valentin; Abad, Jorge; Mediano, Olga; Troncoso, Maria F.; Cano-Pumarega, Irene; Fortuna Gutierrez, Ana Maria; Diaz-Cambriles, Trinidad; Somoza-Gonzalez, Maria; Almendros, Isaac; Farre, Ramon; Gozal, David; Sánchez-de-la-Torre, Manuel
• Is Part Of: European respiratory journal. Volume 51:Issue 3(2018)
• Publication Date: 2018-03-15
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01885-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma. This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea–hypopnoea index (AHI) 0–5 events·h −1 ), mild OSA (AHI 5–15 events·h −1 ) and moderate–severe OSA (AHI >15 events·h −1 ). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable. 360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8–68.0) years and AHI 8.55 (2.8–19.5) events·h −1 ). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate–severe OSA: OR 2.35, p=0.013). In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion. In patients with cutaneous melanoma, OSA is associated with increased expression of a biomarker of tumorigenesis http://ow.ly/mLo430i9Z8j