Association between lung cancer somatic mutations and occupational exposure in never-smokers. Issue 4 (26th October 2017)

• Record Type: Journal Article
• Authors: Paris, Christophe; Do, Pascal; Mastroianni, Bénédicte; Dixmier, Adrien; Dumont, Patrick; Pichon, Eric; Chouaid, Christos; Coudert, Bruno; Foucher, Pascal; Fraboulet, Séverine; Locatelli-Sanchez, Myriam; Baize, Nathalie; Dansin, Eric; Moreau, Lionel; Vincent, Michel; Missy, Pascale; Morin, Franck; Moro-Sibilot, Denis; Couraud, Sébastien
• Other Names: author non-byline.; Souquet Pierre-Jean author non-byline.; Gervais Radj author non-byline.; Doubre Hélène author non-byline.; Pichon Eric author non-byline.; Dixmier Adrien author non-byline.; Monnet Isabelle author non-byline.; Mastroianni Bénédicte author non-byline.; Vincent Michel author non-byline.; Tredaniel Jean author non-byline.; Perrichon Marielle author non-byline.; Foucher Pascal author non-byline.; Coudert Bruno author non-byline.; Moro-Sibilot Denis author non-byline.; Dansin Eric author non-byline.; Dumont Patrick author non-byline.; Moreau Lionel author non-byline.; Debieuvre Didier author non-byline.; Margery Jacques author non-byline.; Quoix Élisabeth author non-byline.; Duvert Bernard author non-byline.; Cellerin Laurent author non-byline.; Baize Nathalie author non-byline.; Taviot Bruno author non-byline.; Coudurier Marie author non-byline.; Cadranel Jacques author non-byline.; Chatellain Patrick author non-byline.; Virally Jérôme author non-byline.; Westeel Virginie author non-byline.; Labrune Sylvie author non-byline.; Le Maignan de Kerangat Laureline author non-byline.; Dot Jean-Marc author non-byline.; Larive Sébastien author non-byline.; Chouaid Christos author non-byline.; Coëtmeur Daniel author non-byline.; Audigier-Valette Clarisse author non-byline.; Gury Jean-Pierre author non-byline.; Odier Luc author non-byline.; Desfemmes-Baleyte Tsellina author non-byline.; Duval Yannick author non-byline.; Merle Patrick author non-byline.; Devouassoux Gilles author non-byline.; Azarian Reza author non-byline.; Barre Patricia author non-byline.; Raffy Olivier author non-byline.; Masson Philippe author non-byline.; Dehette Stéphanie author non-byline.; Toussaint Batbedat Caroline author non-byline.; Oliviero Gérard author non-byline.; Derollez Marc author non-byline.; Paillot Nadine author non-byline.; Dauba Jérôme author non-byline.; Herman Dominique author non-byline.; Rodier Jean-Michel author non-byline.; Bota Suzanna author non-byline.; Brun Philippe author non-byline.; Letanche Geneviève author non-byline.; Khomsi Mohamed author non-byline.; Gentil-Lepecq Béatrice author non-byline.; Ravier Philippe author non-byline.; Hammou Yassine author non-byline.; Barlesi Fabrice author non-byline.; Laize Hélène author non-byline.; Fournel Pierre author non-byline.; Clement-Duchene Christelle author non-byline.; Castelli Joël author non-byline.; Schneider Sophie author non-byline.; Levy Antoine author non-byline.; Jolimoy Geneviève author non-byline.; Pegliasco Hervé author non-byline.; Poudenx Michel author non-byline.; Prevost Alain author non-byline.; Romand Philippe author non-byline.; Bigay-Game Laurence author non-byline.; Suc Etienne author non-byline.;
• Is Part Of: European respiratory journal. Volume 50:Issue 4(2017)
• Publication Date: 2017-10-26
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00716-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure. BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed via a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for EGFR, KRAS, HER2, BRAF and PIK3 mutations, and ALK alterations. Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations (20% versus 44%, p=0.033), and a higher rate of HER2 mutations (18% versus 4%, p=0.084). ALK alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a BRAF mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced HER2 and PIK3 mutation frequency. Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of EGFR mutations. Asbestos exposure is associated with a lower rate of EGFR mutation in lung cancer of never-smokers http://ow.ly/wFUY30fkbcz