Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies. Issue 2 (31st August 2017)

• Record Type: Journal Article
• Authors: Chupp, Geoffrey; Laviolette, Michel; Cohn, Lauren; McEvoy, Charlene; Bansal, Sandeep; Shifren, Adrian; Khatri, Sumita; Grubb, G. Mark; McMullen, Edmund; Strauven, Racho; Kline, Joel N.
• Other Names: author non-byline.; Silvestri Gerard author non-byline.; Dransfield Mark author non-byline.; Haas Andrew author non-byline.; Wahidi Momen author non-byline.; Simoff Michael author non-byline.; Hey Jamie author non-byline.; Ryan Stephen author non-byline.; Kahlstrom Richard author non-byline.; Ferguson Scott author non-byline.; Lamb Carla author non-byline.; Rafeq Samaan author non-byline.; McClelland Marc author non-byline.; Hogarth Kyle author non-byline.; Enfield Kyle author non-byline.; Olivenstein Ron author non-byline.; Toth Jennifer author non-byline.; Lawson Ted author non-byline.; Majid Adnan author non-byline.; Fitzgerald Mark author non-byline.
• Is Part Of: European respiratory journal. Volume 50:Issue 2(2017)
• Publication Date: 2017-08-31
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00017-2017
• Languages: English
• ISSNs: 0903-1936

Abstract

Bronchial thermoplasty is an endoscopic therapy for severe asthma. The previously reported, randomised sham-controlled AIR2 (Asthma Intervention Research 2) trial showed a significant reduction in severe asthma exacerbations, emergency department visits and hospitalisations after bronchial thermoplasty. More "real-world" clinical outcome data is needed. This article compares outcomes in bronchial thermoplasty subjects with 3 years of follow-up from the ongoing, post-market PAS2 (Post-FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma) study with those from the AIR2 trial. 279 subjects were treated with bronchial thermoplasty in the PAS2 study. We compared the first 190 PAS2 subjects with the 190 bronchial thermoplasty-treated subjects in the AIR2 trial at 3 years of follow-up. The PAS2 subjects were older (mean age 45.9 versus 40.7 years) and more obese (mean body mass index 32.5 versus 29.3 kg·m −2 ) and took higher doses of inhaled corticosteroids (mean dose 2301 versus 1961 μg·day −1 ). More PAS2 subjects had experienced severe exacerbations (74% versus 52%) and hospitalisations (15.3% versus 4.2%) in the 12 months prior to bronchial thermoplasty. At year 3 after bronchial thermoplasty, the percentage of PAS2 subjects with severe exacerbations, emergency department visits and hospitalisations significantly decreased by 45%, 55% and 40%, respectively, echoing the AIR2 results. The PAS2 study demonstrates similar improvements in asthma control after bronchial thermoplasty compared with the AIR2 trial despite enrolling subjects who may have had poorer asthma control. A comparison of the results obtained thus far in PAS2 with AIR2 evaluating bronchial thermoplasty in severe asthma http://ow.ly/sB0X30csDuE